Role of the renal nerves in one-kidney, one clip hypertension in rats.
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چکیده
منابع مشابه
Role of the renal nerves in one-kidney, one clip hypertension in rats.
The effects of renal denervation on the onset and maintenance of one-kidney, one clip Goldblatt (1K1C) hypertension were determined. Renal denervation was performed at the time of 1K1C surgery, and was repeated at 3-week intervals to prevent renal nerve regeneration. Denervation delayed the onset of 1K1C hypertension by about 5 weeks, but the final hypertensive state was unaltered. Mean arteria...
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The afferent renal nerves enhance sympathetic activity in the one-kidney, one-clip hypertensive rat. We have also found adenosine-sensitive nerve endings in the renal pelvis that, when stimulated, increase sympathetic activity producing hypertension. To determine whether adenosine, which is excreted when renal blood flow is reduced, activates the afferent renal nerves in one-kidney, one-clip hy...
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Increased sympathetic nervous system activity has been demonstrated in established twokidney, one clip hypertension in the rat. To determine the importance of the renal nerves in this model of hypertension, renal denervation of the clipped kidney (n = IS), renal denotation of the nondlpped kidney (n = 14), sham operation (n = 20), or undlpping (n = 12) was carried out 6 weeks after the onset of...
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One-kidney Goldblatt hypertensive rabbits (New Zealand White) were studied after durations of renal artery clipping that varied from 6 to 17 days. Measurements included arterial pressure (ABP), iliac venous pressure (IVP), left atrial pressure (LAP), cardiac output (CO) (by thermodilution), blood volume (BV), cardiopulmonary volume (CPV), and hindleg thermodilution volume (HLV). These were dete...
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BACKGROUND Angiotensin II (ANG II) is a major factor involved in the progression of chronic renal disease. Although the generation of this vasoactive peptide has been investigated in great detail, only a few studies have hitherto addressed the metabolism of ANG II into fragments such as angiotensin III and IV (ANG III, IV) which may exert physiological effects independent of ANG II. Aminopeptid...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1984
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.6.5.622